DAY 1

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7:45 am Registration; Continental Breakfast

8:30am Welcome: From bench to bedside towards tremor therapy development Overview - Sheng-Han Kuo

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Session 1: Novel brain pathology and genetics of tremor

Moderator: Sheng-Han Kuo

 

8:40am Pathological signatures in essential tremor - Phyllis Faust

9:05am Genetic update on essential tremor - Guy Rouleau

9:30am Genetics of tremor predominant Parkinson’s disease -Joshua Shulman

 

9:55am Refreshment Break

 

Session 2: Animal studies of tremor: what do we learn?

Moderator: Claudia Testa

 

10:15am Frequency control of the cerebellum for tremor generation - Ming-Kai Pan

10:40am Anatomical and physiological underpinnings of dystonia, ataxia, and tremor - Roy Sillitoe

11:05am GABAergic transmission of Purkinje cells in tremor - Esther Krook-Magnuson

 

11:30pm Lunch

 

Session 3: Controversies in the tremor field

 

Debate 1: ET plus: How should we deal with clinical heterogeneity of ET?

Moderator: Hyder Jinnah

 

12:30pm Yes, we should use the term, ET plus (20) - Rodger Elble

12:50pm No, we should drop the term, ET plus - Elan Louis

1:10pm Discussion - Hyder Jinnah

 

Debate 2: What is the best interventional approach for essential tremor?

Moderator: Joohi Jimenez-Shahed

 

1:40pm Deep brain stimulation - Nora Vanegas-Arroyave

2:00pm Focused ultrasound-mediated thalamotomy - Gordon Baltuch

2:20pm Discussion - Joohi Jimenez-Shahed

 

2:50pm Refreshment Break

 

Session 4: Cognition in tremor

Moderator: Kelly Lyons (TRG)

3:15pm Cognitive impairment in essential tremor - Stephanie Cosentino

 

Session 5: Oral presentation of selected posters

Moderator: Theresa Zesiewicz

 

3:40pm 8 mins each presentation, 7 presentation total (non-CME) (56-60 mins)

Excluding pharmaceutical company posters

 

Session 6: Posters and Reception

4:40pm Posters and reception

6:00pm Adjourn

 

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DAY 2

 

7:45am Registration, Continental Breakfast

 

Session 6: Cerebellar physiology and tremor

Moderator: Ming-Kai Pan

 

8:30am Purkinje cell synchrony for tremor generation - Eric Lang

8:55am Complex spike modulation for tremor - Wade Regehr

9:20am Cerebellar circuitry for dystonia and tremor - Kamran Khodakhah

 

9:45am Refreshment Break

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Session 7: Neuroimaging of tremor: Useful biomarkers?

Moderator: Rajesh Pahwa

 

10:05am Basal ganglia and cerebellar circuit in Parkinsonian tremor - Rick Helmich

10:30am Brain network changes in Parkinson’s disease and essential tremor - Daniel Claassen

10:55am Distinct brain circuitry of essential tremor and dystonic tremor - Aparna Wagle Shukla

11:20am Lesion based mapping of tremor circuitry - Michael Fox

 

11:45pm Lunch

Parallel lunch for Young Investigators

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Session 8: Clinical characteristics and video demonstration of diverse tremor disorders

Moderator: Vicki Shanker (New York)

 

12:45pm Clinical characteristics of tremor disorders (18+7) - Steve Frucht (New York)

1:10pm Overlapping phenotypes of tremor and dystonia (18+7) - Aasef Shaikh

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Session 9: Novel DBS approaches for tremor

Moderator: Hyun Joo Cho (NIH)

 

1:35pm Close loop DBS for tremor (18+7) - Helen Bronte-Stewart

2:00pm New DBS targets for tremor (18+7) - Ludy Shih (TRG)

2:25pm Tremor habituation/relapse after DBS and lesion-based therapies (18+7) - Alfonso Fasano (TRG)

 

2:50pm Refreshment Break (20)

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Session 10: Novel pharmacological and toxin therapies for tremor

Moderator: Cindy Comella (TRG)

 

3:10pm Recent pharmacological therapy development for tremor (18+7) -  William Ondo (TRG)

3:35pm Toxin therapy and peripheral modulation for tremor (18+7) Mandar Jog

 

Session 11: Current therapy for tremor- Industry perspective (non-CME)

Moderator: Peter LeWitt (TRG)

 

4:00pm Pipeline development for selective industry partners (10 mins each X 5)

5:00pm Closing remark - Ming-Kai Pan

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