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SCHEDULE

Day 1            April 30th

                       

 7:30 AM           Registration and Continental Breakfast

                       

 8:25 AM           Welcome (5 min)

                              Sheng-Han Kuo & Aparna Wagle Shukla

                       

 Session 1:      Recent Advances in Tremor Physiology and Clinical Science

 Moderator:   Shabbir Merchant

                       

 8:30 AM            The Global Burden of Essential Tremor and the Economic Costs of Treatment 

                               Kandice Kapinos                       

                       

 8:50 AM             Prevalence and Clinical Significance of Common and Rare Tremor Disorders

                                Sanjay Pandey

                       

 9:10 AM             Postmortem-based Diagnostic Criteria for Essential Tremor

                                Phyllis Faust

                       

 9:30 AM             Neuropathological Basis of ET-Dementia

                                Elan Louis

                       

 9:50 AM             Work and Activity Impairment in Individuals with Essential Tremor

                                Ludy Shih

                       

 10:10 AM           Distinguishing Parkinson’s Disease Tremor from Essential Tremor: Clinical and Experimental                                  Tools

                                Matteo Bologna

                       

 10:30 AM            Cerebellar EEG Signatures of Essential Tremor

                                 Ami Kumar 

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 10:40 AM            High Spatiotemporal ECoG Recordings in an Essential Tremor Patient Reveal Frequency-                                         Specific  Spatial Power Distributions in the Primary Motor Cortex

                                 Aaron H Berson

                       

 10:50 AM            Break (20 min)

                       

 Session 2:        Basic and Translational Research of Tremors: What Do We Learn?

 Moderator:     Ilaria Balbo

                       

 11:10 AM            Essential tremor : from Circuitry Dynamics to Therapeutic Responses

                                 Ming-Kai Pan

                       

 11:30 AM            Thalamic Gating of Movement Frequency: Implications in Tremor Disorders

                                  Christopher Chen

                       

 11:50 AM             Neurophysiologic Signatures of Essential Tremor and Implications for DBS

                                  Lauren Hammer

                       

 12:10 PM              Bi-directional Regulation of Cerebellar Physiology of Ataxia and Tremor

                                  Sheng-Han Kuo

                       

 12:30 PM              Purkinje Cell Axonal Pathology of Essential Tremor

                                   Hirofumi Fujita

                       

 12:50 PM               Proteomic Analysis of the Cerebellar – Olivary Tremor Circuit Reveals Myelination and                                               Cholinergic Signaling Defects in Essential Tremor

                                   Giovanni Oliveros

                                           

 Lunch                      1:00 PM to 2:00 PM

                       

 Session 3:            From Mechanisms to Medicine: Identifying the Key Pathophysiological Basis                                        Underlying Essential Tremor and Parkinson’s Disease for Targeted Therapies

 Moderator:         Peter A. LeWitt

                       

 2:00 PM                   Initial Poll

                                     Peter A. LeWitt

                       

 2:05 PM                    Hyper-excitability of the T-type Calcium Channels is the Key Mechanism for Essential                                                  Tremor 

                                      Theresa Zesiewicz

                       

 2:20 PM                    Insufficient GABA Mechanism is the Key Mechanism for Essential Tremor

                                       William Ondo

                       

 2:35 PM                    Dopaminergic Dysfunction: A Central Contributor to Parkinsonian Tremor

                                       Michiel F. Dirkx

                       

 2:50 PM                    Serotonin and not Dopamine: A Central Contributor to Parkinsonian Tremor

                                        Jacopo Pasquini

                       

 3:05 PM                    Discussion

                                        Peter A. LeWitt

                       

 3:30 PM                    Refreshment Break (30 min)

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 Session 4:               Industry Perspective (NON-CME SESSION)

 Moderator:           Daniel Roque

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4:00 PM                        Latest Clinical Evidence on Wearable Neuromodulation with TAPS Therapy

                                         Stuart Isaacson

                       

 4:30 PM                        Industry Partner Presentations 

                       

 5:30 PM                        Panel Discussion - Academic and Industry Collaboration

                                          Moderators: Sheng-Han Kuo & Shabbir  Merchant, Aparna Wagle Shukla & Dietrich                                                  Haubenberger 

                       

 6:00 PM                         Adjourn

                       

 6:30 PM                         Reception and Dinner: Sunset Cruise at Tampa Bay

                       

Day 2            May 1st

                       

 7:30 AM                        Registration; Continental Breakfast

                       

 Session 5:                 Recent Advances in Imaging of Tremor Disorders

 Moderator:              Luca Marsili

                       

 8:10 AM                        New Insights of Dystonic Voice Tremor Imaging

                                           Kristina Simonyan

                       

 8:20 AM                        Enigma Tremor

                                           Arthur Buijink

                       

 8:40 AM                        Updates on Parkinson’s Disease Tremor Imaging

                                           Rick Helmich

                       

 9:00 AM                         Deciphering How Noninvasive TAPS Treats Refractory Essential Tremor:                                                                          Electrophysiologic  Evidence of VIM Modulation and Longitudinal PET-Based                                                              Network  Effects

                                                          Cuong P. Luu  

                       

 9:10 AM                         The Cerebral Mechanisms of Re-emergent Tremor in Parkinson’s Disease

                                                          Kevin Van Den Berg ​ 

                       

 9:20 AM                          Refreshment Break (30 mins)

                       

 Session 6:                  Advances in Therapeutic Development for Tremor

 Moderator:               Jerry D. Fenn

                                            

 10:00 AM                       New Horizons in Tremor Management: Pharmacological Innovations and Clinical Trials

                                            Peter A. LeWitt

                       

 10:20 AM                       Advances in Deep Brain Stimulation Therapy for Tremor Disorders: Evolving Targets                                                  and Targeting Strategies to Achieve Better Neuromodulation Outcomes

                                            Aparna Wagle Shukla

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 10:40 AM                       Thermal Lesioning with Precision: Updates on Focused Ultrasound Therapy for Tremor

                                            Antonella Macerollo

                       

 11:00 AM                       Machine Learning Approaches for Understanding and Managing Tremor Disorders

                                            Muthuraman Muthuraman

                       

 11:20 AM                       Artificial Intelligence in Tremor Diagnosis and Management: Current Applications and  

                                            Future Directions

                                            Nienke A Timmermans

                       

 11:40 AM                       Thalamic High-Frequency Oscillations During Speech Production in Essential  Tremor                                                with  and  without Voice Tremor

                                                       Giovanni Battistella

                                                

 11:50 AM                        Movement Neurophysiology Studies for Tremor: Clinical Practice Patterns and                                                                 Standardization

                                                        Marcus Callister

                       

 12:00 PM                         Patient-Reported Outcome Measure of the Functional Impact of Essential                                                                          Tremor on Activities of Daily Living: TETRAS PRO

                                              Ludy Shih

                       

 12:15 PM                         Poster Session, Lunch and Learn

                       

 Session 7:                   Advances in Analysis of Tremor

 Moderator:                Jun Yu

                       

 1:30 PM                           Electrophysiological Tools for Tremor Evaluation: What Every Clinician Should Know

                                             Katie Longardner & Marcus Callister

                       

 1:50 PM                           Decoding Head Tremor: Electrophysiological Tools for Differential Diagnosis and                                                         Management

                                             Aasef Shaikh

                       

 2:10 PM                            Smart Wearables for Tremor Detection: Algorithms, Accuracy, and Clinical Relevance

                                              Steven Charles

                       

 Session 8:                    Clinical and Research Mentoring (60 min)

 Moderator:                 Katie Longardner

                       

 2:30 PM                             What  Do We Need to Move Tremor Research Forward? Perspectives for the Next                                                         Generation

                                               Robert A. Hauser, Holly Shill, Abhishek Lenka & Daniel Roque

                       

 3:30 PM                             Refreshment Break (20 min)

                       

 Session 9:                     Challenging Cases & Video Rounds
                       

 3:50 PM                              Tremor Video Rounds: Case-Based Learning and Diagnostic Pearls

                                                Steven Frucht & Hyder Jinnah

                       

 4:50 PM                               Closing Remarks

                                                 Sheng-Han Kuo & Aparna Wagle Shukla

SPEAKERS

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Ilaria Balbo, PhD
 

Postdoctoral Research Fellow

Columbia University Irving Medical Center
New York, New York

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Aaron H. Berson, PhD
 

University of Pennsylvania

Philadelphia, Pennsylvania

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Matteo Bologna MD, PhD
 

Associate Professor of Neurology

University of Rome La Sapienza
Rome, Italy

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Arthur Buijink, MD PhD

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Neurologist

Amsterdam University Medical Center

Amsterdam, the Netherlands

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Marcus Callister, MD

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Clinician Investigator, Instructor
NSI Neuro Behavioral MGPO, Mass General Research Institute

Massachusetts General Hospital

Boston, Massachusetts

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Steven Charles, PhD

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Neuroscience Center Director, Associate Professor, Mechanical Engineering

Brigham Young University 

Provo, Utah

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Christopher Chen, PhD

 

Assistant Professor, Neuroscience and Experimental Therapeutics

Penn State College of Medicine

Hershey, Pennsylvania

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Michiel F. Dirkx, MD, PhD
 

Neurologist

Radboud University Medical Center

 Nijmegen, Netherlands

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Phyllis L. Faust, MD, PhD
 

Professor, Department of Pathology and Cell Biology

Columbia University Vagelos College of Physicians and Surgeons

New York, New York

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Jerry Fenn, MD, PhD
 

Jr. Movement Disorders Fellow

Norman Fixel Institute for Neurological Diseases
Gainsville, FL

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Steven Frucht, MD
 

Professor, Department of Neurology Director, Division of Parkinson's and Movement Disorders

NYU Grossman School of Medicine

New York, New York

Hirofumi Fujita, MD, PhD
 

Assistant Professor

Cain Scholar in Mobility Disorders

UT Southwestern Medical Center
Dallas, Texas

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Lauren H Hammer, MD, PhD
 

Assistant Professor of Neurology Hammer Neuromodulation Laboratory

University of Pennsylvania

Philadelphia, Pennsylvania

Robert A. Hauser MD, MBA
 

Professor of Neurology

Director
USF Parkinson’s Disease and Movement Disorders Center
Tampa, Florida

Rick Helmich, MD, PhD
 

Consultant Neurologist

Radboud University Nijmegen Medical Center

Nijmegen, Netherlands

Hyder Jinnah, MD, PhD
 

Departments of Neurology and Human Genetics

Emory University School of Medicine
Atlanta, Georgia

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Kandice Kapinos, PhD
 

Adjunct Associate Professor

UT Southwestern Medical Center
Dallas, Texas

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Ami Kumar PhD
 

Postdoctoral Research Fellow

Columbia University Irving Medical Center
New York, New York

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Sheng-Han Kuo, MD
 

Associate Professor of Neurology

Columbia University Irving Medical Center
New York, New York

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Abhishek Lenka, MD, PhD
 

Assistant Professor

Department of Neurology 

VCU Parkinson's & Movement Disorders Center 

VCU Comprehensive Autonomic Center

Virginia Commonwealth University School of Medicine
Richmond, Virginia

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Peter A. LeWitt, MD
 

Departments of Neurology

Henry Ford Hospital and Wayne State University School of Medicine

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Katherine Longardner, MD

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Assistant Professor of Neurosciences

University of California San Diego

La Jolla, Califonia

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Elan D. Louis, MD, MS
 

Professor of Neurology

Linda and Mitch Hart Distinguished Chair in Neurology

University of Texas Southwestern Medical Center
Dallas, Texas

Antonella Macerollo, MD PhD, FRCP FEBN F

Antonella Macerollo, MD PhD, FRCP FEBN FEAN

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Consultant Neurologist (Movement Disorders, DBS, MRIgFUS)

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Clinical Associate Professor (Honorary), University of Liverpool

Liverpool, United Kingdom

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Luca Marsili, MD
 

 Movement Disorders Clinical Fellow and Instructor of Neurology at the University of Cincinnati (OH).

Cincinnati Ohio

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Shabbir Merchant ,MD
 

 Neurologist

Beth Israel Deaconess Medical Center

Boston Massachusettes

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Muthuraman Muthuraman, PhD
 

Associate Professor

Chair of the Informatics for Medical Technology

University Augsburg

​Augsburg, Germany

Giovanni Oliveros
 

Postdoctoral Research Scientist in the Department of Pathology and Cell Biology, Dept of Pathology

Columbia University Irving Medical Center
New York, New York

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William Ondo, MD
 

Director-Movement Disorders Clinic

Houston Methodist Neurological Institute
Houston, Texas

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Ming-Kai Pan, MD, PhD
 

Assistant Professor of Pharmacology Institute and Molecular Imaging Center

National Taiwan University
Taipei, Taiwan

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Daniel Roque, MD

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Professor of Neurology

Vice Chair of Ambulatory Affairs

Director of the UNC Movement Disorders Neuromodulation Program

Adjunct Associate Professor, UNC Neurosurgery

UNC Hospitals Neurology Clinic

Chapel Hill, NC

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Aasef Shaikh, MD, PhD
 

Penni and Stephen Weinberg Chair in Brain Health

Vice Chair for Research, Department of Neurology

University Hospitals
Cleveland, OH

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Kristina Simonyan, MD, PhD
 

John W. Merriam and William W. Montgomery Professor and Vice Chair for Clinical Research

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Investigator in Neurology

Massachusetts General Hospital

Boston, Massachusetts

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​Nienke-Timmermans PhD

 

PhD candidate

Radboud University Medical Center

Nijmegen, Netherlands

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Kevin van den berg 

 

PhD candidate

Radboud University Medical Center

Nijmegen, Netherlands

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Sanjay, Pandey MBBS, MD, DNB, DM, FIAN
 

Professor and Head

Department of Neurology and Stroke Medicine

Amrita Institute of Medical Sciences
Faridabad, India

Jacopo Pasquini, MD
 

Post Doctoral Researcher

University of Pisa
Pisa PI, Italy

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Ludy Shih, MD, MMSc, FAAN, FANA
 

Department of Neurology

Beth Israel Deaconess Medical Center

Harvard Medical School
Boston, Massachusetts 

Holly Shill, MD, FAAN
 

Director

 Lonnie and Muhammad Ali Movement Disorder Center, Barrow Neurological Institute

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Bob and Renee Parsons Chair in Parkinson’s Disease and Movement Disorders
Phoenix, Arizona

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Aparna Wagle Shukla, MD
 

Professor of Neurology Director, Clinical Trials

University of Florida Health
Gainesville, Florida 

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Theresa Zesiewicz, MD, FAAN
 

Professor

Department of Neurology

University of South Florida
Tampa, Florida

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Jun Yu, MD, FAHA

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Professor and Vice Chair

Lewis Kats School of Medicine

Philadelphia, Pennsymvania 

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​Endorsed by the International Parkinson and Movement Disorder Society

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